AustralieFrV1, Main, Exploration, bibRecord, 002975

Present and Future Therapies of Hepatitis B: From Discovery to Cure

Identifieur interne : 002975 ( Main/Exploration ); précédent : 002974; suivant : 002976

Present and Future Therapies of Hepatitis B: From Discovery to Cure

Auteurs : T. Jake Liang ; Timothy M. Block ; Brian J. Mcmahon ; Marc G. Ghany ; Stephan Urban [Allemagne] ; Ju-Tao Guo ; Stephen Locarnini [France] ; Fabien Zoulim [Australie] ; Kyong-Mi Chang ; Anna S. Lok

Source :

Hepatology (Baltimore, Md.) [ 0270-9139 ] ; 2015.

RBID : PMC:4681668

Descripteurs français

KwdFr :
- Antiviraux (usage thérapeutique), Découverte de médicament, Humains, Hépatite B (traitement médicamenteux), Induction de rémission, Prévision.
MESH :
- traitement médicamenteux : Hépatite B.
- usage thérapeutique : Antiviraux.
- Découverte de médicament, Humains, Induction de rémission, Prévision.

English descriptors

KwdEn :
- Antiviral Agents (therapeutic use), Drug Discovery, Forecasting, Hepatitis B (drug therapy), Humans, Remission Induction.
MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Hepatitis B.
- Drug Discovery, Forecasting, Humans, Remission Induction.

Abstract

Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require life-long therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase and we will likely see more of them moving along the development pipeline. With a growing interest in and effort to developing more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681668

DOI: 10.1002/hep.28025
PubMed: 26239691
PubMed Central: 4681668

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Present and Future Therapies of Hepatitis B: From Discovery to Cure</title>
<author><name sortKey="Liang, T Jake" sort="Liang, T Jake" uniqKey="Liang T" first="T. Jake" last="Liang">T. Jake Liang</name>
<affiliation><nlm:aff id="A1">Liver Diseases Branch, NIDDK, NIH, Bethesda, MD. USA</nlm:aff>
<wicri:noCountry code="subfield">MD. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Block, Timothy M" sort="Block, Timothy M" uniqKey="Block T" first="Timothy M." last="Block">Timothy M. Block</name>
<affiliation><nlm:aff id="A2">Baruch S. Blumberg Institute, Doylestown, PA. USA</nlm:aff>
<wicri:noCountry code="subfield">PA. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mcmahon, Brian J" sort="Mcmahon, Brian J" uniqKey="Mcmahon B" first="Brian J." last="Mcmahon">Brian J. Mcmahon</name>
<affiliation><nlm:aff id="A3">National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK. USA</nlm:aff>
<wicri:noCountry code="subfield">AK. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ghany, Marc G" sort="Ghany, Marc G" uniqKey="Ghany M" first="Marc G." last="Ghany">Marc G. Ghany</name>
<affiliation><nlm:aff id="A1">Liver Diseases Branch, NIDDK, NIH, Bethesda, MD. USA</nlm:aff>
<wicri:noCountry code="subfield">MD. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Urban, Stephan" sort="Urban, Stephan" uniqKey="Urban S" first="Stephan" last="Urban">Stephan Urban</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Dept of Infectious Diseases, Molecular Virology and German Center for Infection Diseases (DZIF), Univ Hospital Heidelberg, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dept of Infectious Diseases, Molecular Virology and German Center for Infection Diseases (DZIF), Univ Hospital Heidelberg, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guo, Ju Tao" sort="Guo, Ju Tao" uniqKey="Guo J" first="Ju-Tao" last="Guo">Ju-Tao Guo</name>
<affiliation><nlm:aff id="A2">Baruch S. Blumberg Institute, Doylestown, PA. USA</nlm:aff>
<wicri:noCountry code="subfield">PA. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Hepatology Dept, Lyon Univ & CRCL, INSERM U1052, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hepatology Dept, Lyon Univ & CRCL, INSERM U1052, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang, Kyong Mi" sort="Chang, Kyong Mi" uniqKey="Chang K" first="Kyong-Mi" last="Chang">Kyong-Mi Chang</name>
<affiliation><nlm:aff id="A7">Dept of Medicine, Philadelphia VAMC & University of Pennsylvania, Philadelphia, PA. USA</nlm:aff>
<wicri:noCountry code="subfield">PA. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lok, Anna S" sort="Lok, Anna S" uniqKey="Lok A" first="Anna S." last="Lok">Anna S. Lok</name>
<affiliation><nlm:aff id="A8">Div of Gastroenterology and Hepatology, Univ of Michigan, Ann Arbor, MI. USA</nlm:aff>
<wicri:noCountry code="subfield">MI. USA</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26239691</idno>
<idno type="pmc">4681668</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681668</idno>
<idno type="RBID">PMC:4681668</idno>
<idno type="doi">10.1002/hep.28025</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">002022</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002022</idno>
<idno type="wicri:Area/Pmc/Curation">001E76</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001E76</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D79</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D79</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002684</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002684</idno>
<idno type="wicri:Area/PubMed/Curation">002615</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002615</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002615</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002615</idno>
<idno type="wicri:Area/Ncbi/Merge">002904</idno>
<idno type="wicri:Area/Ncbi/Curation">002904</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002904</idno>
<idno type="wicri:doubleKey">0270-9139:2015:Liang T:present:and:future</idno>
<idno type="wicri:Area/Main/Merge">002975</idno>
<idno type="wicri:Area/Main/Curation">002975</idno>
<idno type="wicri:Area/Main/Exploration">002975</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Present and Future Therapies of Hepatitis B: From Discovery to Cure</title>
<author><name sortKey="Liang, T Jake" sort="Liang, T Jake" uniqKey="Liang T" first="T. Jake" last="Liang">T. Jake Liang</name>
<affiliation><nlm:aff id="A1">Liver Diseases Branch, NIDDK, NIH, Bethesda, MD. USA</nlm:aff>
<wicri:noCountry code="subfield">MD. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Block, Timothy M" sort="Block, Timothy M" uniqKey="Block T" first="Timothy M." last="Block">Timothy M. Block</name>
<affiliation><nlm:aff id="A2">Baruch S. Blumberg Institute, Doylestown, PA. USA</nlm:aff>
<wicri:noCountry code="subfield">PA. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mcmahon, Brian J" sort="Mcmahon, Brian J" uniqKey="Mcmahon B" first="Brian J." last="Mcmahon">Brian J. Mcmahon</name>
<affiliation><nlm:aff id="A3">National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK. USA</nlm:aff>
<wicri:noCountry code="subfield">AK. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ghany, Marc G" sort="Ghany, Marc G" uniqKey="Ghany M" first="Marc G." last="Ghany">Marc G. Ghany</name>
<affiliation><nlm:aff id="A1">Liver Diseases Branch, NIDDK, NIH, Bethesda, MD. USA</nlm:aff>
<wicri:noCountry code="subfield">MD. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Urban, Stephan" sort="Urban, Stephan" uniqKey="Urban S" first="Stephan" last="Urban">Stephan Urban</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Dept of Infectious Diseases, Molecular Virology and German Center for Infection Diseases (DZIF), Univ Hospital Heidelberg, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dept of Infectious Diseases, Molecular Virology and German Center for Infection Diseases (DZIF), Univ Hospital Heidelberg, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guo, Ju Tao" sort="Guo, Ju Tao" uniqKey="Guo J" first="Ju-Tao" last="Guo">Ju-Tao Guo</name>
<affiliation><nlm:aff id="A2">Baruch S. Blumberg Institute, Doylestown, PA. USA</nlm:aff>
<wicri:noCountry code="subfield">PA. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Hepatology Dept, Lyon Univ & CRCL, INSERM U1052, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hepatology Dept, Lyon Univ & CRCL, INSERM U1052, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, VIC, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victorian Infectious Diseases Reference Laboratory, Doherty Institute, Melbourne, VIC</wicri:regionArea>
<wicri:noRegion>VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang, Kyong Mi" sort="Chang, Kyong Mi" uniqKey="Chang K" first="Kyong-Mi" last="Chang">Kyong-Mi Chang</name>
<affiliation><nlm:aff id="A7">Dept of Medicine, Philadelphia VAMC & University of Pennsylvania, Philadelphia, PA. USA</nlm:aff>
<wicri:noCountry code="subfield">PA. USA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lok, Anna S" sort="Lok, Anna S" uniqKey="Lok A" first="Anna S." last="Lok">Anna S. Lok</name>
<affiliation><nlm:aff id="A8">Div of Gastroenterology and Hepatology, Univ of Michigan, Ann Arbor, MI. USA</nlm:aff>
<wicri:noCountry code="subfield">MI. USA</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Hepatology (Baltimore, Md.)</title>
<idno type="ISSN">0270-9139</idno>
<idno type="eISSN">1527-3350</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term>
<term>Drug Discovery</term>
<term>Forecasting</term>
<term>Hepatitis B (drug therapy)</term>
<term>Humans</term>
<term>Remission Induction</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (usage thérapeutique)</term>
<term>Découverte de médicament</term>
<term>Humains</term>
<term>Hépatite B (traitement médicamenteux)</term>
<term>Induction de rémission</term>
<term>Prévision</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis B</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite B</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Drug Discovery</term>
<term>Forecasting</term>
<term>Humans</term>
<term>Remission Induction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Découverte de médicament</term>
<term>Humains</term>
<term>Induction de rémission</term>
<term>Prévision</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require life-long therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase and we will likely see more of them moving along the development pipeline. With a growing interest in and effort to developing more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Bade-Wurtemberg</li>
<li>District de Karlsruhe</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Heidelberg</li>
<li>Lyon</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Block, Timothy M" sort="Block, Timothy M" uniqKey="Block T" first="Timothy M." last="Block">Timothy M. Block</name>
<name sortKey="Chang, Kyong Mi" sort="Chang, Kyong Mi" uniqKey="Chang K" first="Kyong-Mi" last="Chang">Kyong-Mi Chang</name>
<name sortKey="Ghany, Marc G" sort="Ghany, Marc G" uniqKey="Ghany M" first="Marc G." last="Ghany">Marc G. Ghany</name>
<name sortKey="Guo, Ju Tao" sort="Guo, Ju Tao" uniqKey="Guo J" first="Ju-Tao" last="Guo">Ju-Tao Guo</name>
<name sortKey="Liang, T Jake" sort="Liang, T Jake" uniqKey="Liang T" first="T. Jake" last="Liang">T. Jake Liang</name>
<name sortKey="Lok, Anna S" sort="Lok, Anna S" uniqKey="Lok A" first="Anna S." last="Lok">Anna S. Lok</name>
<name sortKey="Mcmahon, Brian J" sort="Mcmahon, Brian J" uniqKey="Mcmahon B" first="Brian J." last="Mcmahon">Brian J. Mcmahon</name>
</noCountry>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Urban, Stephan" sort="Urban, Stephan" uniqKey="Urban S" first="Stephan" last="Urban">Stephan Urban</name>
</region>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Locarnini, Stephen" sort="Locarnini, Stephen" uniqKey="Locarnini S" first="Stephen" last="Locarnini">Stephen Locarnini</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002975 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002975 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4681668
   |texte=   Present and Future Therapies of Hepatitis B: From Discovery to Cure
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26239691" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Present and Future Therapies of Hepatitis B: From Discovery to Cure

Present and Future Therapies of Hepatitis B: From Discovery to Cure

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.